Behavioral studies on drug dependence in rats

Behavioral Pharmacology of Human Drug Dependence, 37

Like other reinforcing stimuli, drug effects may vary with the reinforcement history of an individual. Data are presented which demonstrate that histories contribute to individual differences in response to reinforcement contingencies and modification of maladaptive behavioral persistence. Possible relevance of these findings to an understanding of drug effects in humans is discussed.

Pharmacological studies on drug dependence in rodents: dependence on opioids and CNS depressants.

Physical and psychic dependence on opioids and CNS depressants in rodents were examined using the drug-admixed food (DAF) method. A comparison of several methods for developing physical dependence on opioids was made. The DAF method has the advantage of rapidly inducing a high degree of physical dependence without causing morbidity or mortality. When morphine-dependent rats were pretreated with...

Commentary: New View on Treatment of Drug Dependence

In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtain...

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

Behavioral Treatments for Drug Abuse and Dependence, 137